When you suffer from mental conditions like depression, stress and anxiety, etc. do you think positive affirmation can work? While you might try repeating positive affirmation, it would be more of forced activity rather than truly believing in it.  When you have mental health issues positive affirmation feels fake and doesn’t bring any real relief. In fact, some studies suggest that positive affirmations, often recommended as a quick fix, may actually worsen symptoms for some people struggling with these conditions.