Moderate alcohol consumption is generally considered safe for most adults: up to one drink per day for women and up to two drinks per day for men. One drink typically equals 14 grams of pure alcohol (e.g., one 12-ounce beer, 5-ounce wine, or 1.5-ounce spirits). Exceeding these limits increases risks of health issues like liver disease, heart problems, and addiction. Individual tolerance and health conditions also influence safe consumption levels.