I am more for holistic, alternative which includes herbals as a first resort. However, I'm not against using OTC medicines. If you do use them, be sure to follow the dose & check for interactions, even with herbals. 
Is there any kind of OTC medicine that you have found you need to use quite often? While I'm for natural, I still have to take Advil if I get a pounding headache as Meadowsweet doesn't help.